Grantria®

“Elevate Your Skin Health & Wellness with Grantria’s Triple Bioactive Magic”

Beauty From Within

GRANTRIA®: The secret to Glowing skin

Meet GRANTRIA®: a unique pomegranate extract designed for vibrant skin. Its triple bioactives shield against UV damage, promote skin rejuvenation, and combat oxidative stress.

Key Features

Novelty

Discover how GRANTRIA® is your ultimate solution for vibrant skin

Nowadays, every cosmetic industry and skin care products contain naturally extracted Punicic acid and Ellagic acid from Pomegranate. Punicic acid stimulates keratinocyte cell proliferation and induces regeneration of the epidermis, essential for overall skin glow. Ellagic acid, an antioxidant found in various foods, shields against UV-induced oxidative stress and ageing. However, its limited solubility and permeability reduce intestinal bioavailability.

Any solution to increase the bioavailability?

GRANTRIA® pioneers pomegranate-based innovation, manufactured through proprietary encapsulation technology (ADOP) boasting an exclusive ratio of the triple bioactives – ellagic acid, punicalagin, and punicic acid that transforms it into an antioxidant powerhouse. The novel ADOP technology boosts Punicalagin/Ellagic acid absorption in the intestines, minimizing gut metabolism to Urolithins.

Grantria, a unique combination of the tri-actives, is manufactured through a proprietary ADOP technology. ADOP

Science

GRANTRIA® and it’s Development

ADOP

ADOP is an innovative method designed to combine oil-based actives and powder actives into a free-flowing powder with improved characteristics.It’s a water-based system with a natural, clean label carrier matrix, aligning with our sustainability efforts.

Ellagic acid and Punicalgins play a significant role in managing skin pigmentation and promoting skin radiance by inhibiting Tyrosinase enzymes responsible for melanogenesis, stimulating the synthesis of type I procollagen, and inhibiting matrix metalloproteinase-1 (MMP-1), which is linked to skin ageing. Punicic acid stimulates keratinocytes in the skin to reverse damage, rejuvenate the skin, and unveil a more youthful appearance, while also enhancing collagen production.

Reactive Oxygen Species (ROS), generated by UV rays and pollution, harm the skin by causing wrinkles and impairing its ability to repair itself. Grantria®, a potent polyphenolic super antioxidant, reduces ROS levels, protecting the skin.

Grantria® is a technology-driven composite containing Punicic acid, Punicalagins, and Ellagic acid, offering comprehensive skincare benefits with synergistic effects.

GRANTRIA® is manufactured from a facility carrying all the necessary global accreditations and regulatory approvals

Grantria®'s Triple-Active Innovation: Revolutionizing Women's Wellness

Discover the remarkable benefits of pomegranate (scientifically known as Punica granatum L.) for women’s well-being. Pomegranate, a natural wonder, has a rich history as a traditional remedy for addressing hormonal imbalances, and here’s why it’s a game-changer:
At Grantria®, we’ve harnessed these incredible attributes of pomegranate in our unique product, Grantria®. Grantria® may be your trusted partner for achieving and maintaining optimal women’s health though the clinical studies are pending.

Estrogen-Like Effects

Pomegranate contains compounds that mimic estrogen,
offering a natural solution for managing hormonal
fluctuations.

Antioxidant

Loaded with potent antioxidants like polyphenols, tannin,
and anthocyanin, pomegranate helps combat oxidative stress,
supporting your overall health.

Anti-Cancer Properties

The unique blend of pomegranate juice, seeds, and peel provides
a wealth of phytoestrogens, genistein, and steroid hormones that
have shown promise in the treatment of prostate and
breast cancer.

Menopausal Relief

Pomegranate seed oil has been noted for its effectiveness in
alleviating urogenital symptoms associated with menopause.
Thanks to its phytoestrogens, unsaturated fatty acids, sex
steroids, amino acids, and polyphenols, it can help women
navigate this stage of life more comfortably.

Human Clinical Evidence of GRANTRIA®

Crow’s feet wrinkles

UV Pigmentation

Skin texture improvement

Skin Glow and radiance

Dark Spots/Acne/Pores

Change in Tyrosinase Level

35 to 65 Years Age Group

Skin Problems

300 Mg

60 Days

80 Subjects

Women’s Health

48%

Significant Improvement of around 48% s in Clinical score of Crow’s feet wrinkles observed in subjects supplemented with Grantria on Day 60.

1.2%

The test group exhibited a 1.2% reduction in UV pigmentation compared to placebo during the study Phase.

43.14%

Significant Improvement of 43.12% skin texture observed in subjects supplemented with Grantria

42.8%

Significant Improvement in skin radiance observed in subjects supplemented with Grantria on Day 60.

4.6%

The Test product group exhibited significant improvement (4.6% Reduction in pore) during study period.

3%

The test product has shown around 3% drop in Tyrosinase levels, where as Placebo group shown a negative effect.

Mechanism Of Action

References:

1.Discover the remarkable benefits of pomegranate (scientifically known as Punica granatum L.) for women’s well-being. Pomegranate, a natural wonder, has a rich history as a traditional remedy for addressing hormonal imbalances, and here’s why it’s a game-changer:
2.Yang, Hsin-Ling, et al. “The anti-melanogenic effects of ellagic acid through induction of autophagy in melanocytes and suppression of UVA-activated αMSH pathways via Nrf2 activation in keratinocytes.” Biochemical Pharmacology 185 (2021): 114454.
3.C.V. Ortiz-Ruiz, et al., Action of ellagic acid on the melanin biosynthesis pathway, J Dermatol Sci(2016)
4.Singh RP, Chidambara Murthy KN, Jayaprakasha GK. Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models. J Agric Food Chem. 2002;50(1):81–86.
5.Aslam MN, Lansky EP, Varani J. Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. J Ethnopharmacol. 2006;103(3):311–318
6.Hassan M, Shahzadi S, Kloczkowski A. Tyrosinase Inhibitors Naturally Present in Plants and Synthetic Modifications of These Natural Products as Anti-Melanogenic Agents: A Review. Molecules. 2023 Jan 2;28(1):378. doi: 10.3390/molecules28010378. PMID: 36615571; PMCID: PMC9822343.
7.Yoshimura M, Watanabe Y, Kasai K, Yamakoshi J, Koga T: Inhibitory effect of an ellagic acid-rich pomegranate extracts on tyrosinase activity and ultraviolet-induced pigmentation. Biosci, Biotechnol, Biochem 2005, 69:2368–2373.
8.Fawole OA, Makunga NP, Opara UL. Antibacterial, antioxidant and tyrosinase-inhibition activities of pomegranate fruit peel methanolic extract. BMC Complement Altern Med. 2012 Oct 30;12:200. doi: 10.1186/1472-6882-12-200. PMID: 23110485; PMCID: PMC3527236.
9.Ebanks JP, Wickett RR, Boissy RE. Mechanisms regulating skin pigmentation: the rise and fall of complexion coloration. Int J Mol Sci. 2009 Sep 15;10(9):4066-4087. doi: 10.3390/ijms10094066. PMID: 19865532; PMCID: PMC2769151

CLINICAL STUDIES

Significant Improvement of around 48% observed in subjects supplemented with Grantria

Significant Improvement in skin roughness of around 43.14% observed in subjects with Grantria

Grantria supplementation has helped in 4.6 % drop in Pore values measured by VisioScan

Gremin supplementation test group exhibited a 1.2% reduction in UV pigmentation compared to placebo

Grantria supplementation has helped in 4.6 % drop in Pore values measured by VisioScan

Gremin supplementation test group exhibited a 1.2% reduction in UV pigmentation compared to placebo

A 3 % drop in Tyrosinase levels were observed in case of Test group and the changes were relatively better than Placebo group.

This suggests that the Grantria® capsules exhibit a promising effect as a tyrosinase inhibitor, contributing to the reduction of hyperpigmentation, UV spots and improving skin radiance.

Positioning

The Story of Grantria

Zeus Hygia proudly presents GRANTRIA®, a distinctive fusion of naturally occurring tri-actives: ellagic
acid, punicic acid, and punicalagins, meticulously crafted using our exclusive ADOP technology.
Grantria®, backed with multiple scientific studies can be positioned in various wellness segments

SKIN GLOW

COSMECEUTICAL

ANTI-WRINKLES

WOMEN’S HEALTH

HEALTHY AGEING

MENOPAUSE RELIEF

DOSAGE:

300 mg per day once or two times a day

Regulatory Landscape

GRANTRIA® contains all food ingredients complying with European,US and other international
regulations. Grantria® falls under old dietary ingredient lists developed by the American Herbal
Products Association (AHPA), Council for Responsible Nutrition (CRN), Natural Products
Association (NPA) and the United Natural Products Alliance (UNPA).

Applications

Powder

Capsules

Ready To Drink Poweder Mix

Powder

Capsules

Shots

Get in Touch

Ready to elevate your nutraceutical and pharmaceutical products with our premium herbal extracts?
Contact our team today to discuss your needs, request samples, or place an order. We look forward to
becoming your trusted partner in delivering natural, high-quality solutions to your customers.

ZeusHygia LifeSciences Private Ltd First Floor, Plot No.47 RaviRaja industries Technocrats Industrial Estate, Balanagar, Hyderabad, Telangana ,India-500037

+91 40 - 48 53 95 55

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